Investigating the post-stimulus undershoot of the BOLD signal - A simultaneous fMRI and fNIRS study

被引:96
作者
Schroeter, ML
Kupka, T
Mildner, T
Uludag, K
von Cramon, DY
机构
[1] Max Planck Inst Human Cognit & Brain Sci, D-04103 Leipzig, Germany
[2] Univ Leipzig, Day Clin Cognit Neurol, D-04103 Leipzig, Germany
[3] Univ Calif San Diego, FMRI Ctr, Dept Radiol, La Jolla, CA 92039 USA
关键词
BOLD signal; near-infrared spectroscopy; post-stimulus undershoot;
D O I
10.1016/j.neuroimage.2005.09.048
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Measuring the hemodynamic response with functional magnetic resonance imaging (fMRI) together with functional near-infrared spectroscopy (MIRS) may overcome limitations of single-method approaches. Accordingly, we measured the event-related hemodynamic response with both imaging methods simultaneously in young subjects during visual stimulation. An intertrial interval of 60 s was chosen to include the prolonged post-stimulus undershoot of the blood oxygenation level dependent (BOLD) signal. During visual stimulation, the BOLD signal, oxy-, and total hemoglobin (Hb) increased, whereas deoxy-HI) decreased. The post-stimulus period was characterized by an undershoot of the BOLD signal, oxy-Hb, and an overshoot of deoxy-Hb. Total Hb as measured by fNIRS returned to baseline immediately after the end of stimulation. Results suggest that the post-stimulus events as measured by fNIRS are dominated by a prolonged high-level oxygen consumption in the microvasculature. The contribution of a delayed return of blood volume to the BOLD post-stimulus undershoot in post-capillary veins as suggested by the Balloon and Windkessel models remains ambiguous. Temporal changes in the BOLD signal were highly correlated with deoxy-Hb, with lower correlation values for oxy- and total Hb. Furthermore, data show that fNIRS covers the outer I cm of the brain cortex. These results were confirmed by simultaneous fMRI/fNIRS measurements during rest. In conclusion, multimodal imaging approaches may contribute to the understanding of neurovascular coupling. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:349 / 358
页数:10
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