'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

被引：272

作者：

Stecher, Baerbel ^{[1
,2
]}

Maier, Lisa ^{[3
]}

Hardt, Wolf-Dietrich ^{[3
]}

机构：

[1] Univ Munich, German Ctr Infect Res, D-80336 Munich, Germany

[2] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany

[3] ETH, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; SEROVAR TYPHIMURIUM COLITIS; ANTIBIOTIC-RESISTANCE GENES; LONG-TERM IMPACTS; ESCHERICHIA-COLI; INTESTINAL MICROBIOTA; SALMONELLA-TYPHIMURIUM; CONJUGATIVE TRANSFER; HOST; INFLAMMATION;

D O I：

10.1038/nrmicro2989

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hundreds of bacterial species make up the mammalian intestinal microbiota. Following perturbations by antibiotics, diet, immune deficiency or infection, this ecosystem can shift to a state of dysbiosis. This can involve overgrowth (blooming) of otherwise under-represented or potentially harmful bacteria (for example, pathobionts). Here, we present evidence suggesting that dysbiosis fuels horizontal gene transfer between members of this ecosystem, facilitating the transfer of virulence and antibiotic resistance genes and thereby promoting pathogen evolution.

引用

页码：277 / 284

页数：8

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