Immunotherapy for fungal infections

被引：27

作者：

Armstrong-James, Darius ^{[2
]}

Harrison, Thomas S. ^{[1
]}

机构：

[1] St Georges Univ London, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Sect Infect Dis & Immun, London, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2012年 / 15卷 / 04期

基金：

英国医学研究理事会;

关键词：

INTERFERON-GAMMA IMMUNOTHERAPY; SURVEILLANCE NETWORK TRANSNET; CHRONIC GRANULOMATOUS-DISEASE; CRYPTOCOCCAL MENINGITIS; HEMATOPOIETIC TRANSPLANTATION; INVASIVE ASPERGILLOSIS; THYMOSIN ALPHA-1; DENDRITIC CELLS; AMPHOTERICIN-B; COMBINATION;

D O I：

10.1016/j.mib.2012.06.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Invasive fungal infections have become a major cause of mortality in immunocompromised individuals. Despite the current availability of number of highly active antifungal agents, overall mortality remains around 40%. Importantly, it is clear that a failure to restore host immunity leads to worse outcomes. These observations provide clear rationale for the development of novel immunotherapies to improve outcomes in immunocompromised individuals with invasive fungal infections. In this article we summarise the key advances that have been made in the field of immunotherapy for fungal infections in recent years, with a particular focus on clinical studies of interferon-gamma therapy, adoptive T cell therapy, and gene therapy for chronic granulomatous disorder. In addition a number of pre-clinical approaches are reviewed.

引用

收藏

页码：434 / 439

页数：6

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