Radioimmunotherapy Is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection

被引：46

作者：

Bryan, Ruth A. ^{[1
]}

Jiang, Zewei ^{[1
]}

Howell, Robertha C. ^{[1
]}

Morgenstern, Alfred ^{[4
]}

Bruchertseifer, Frank ^{[4
]}

Casadevall, Arturo ^{[2
,3
]}

Dadachova, Ekaterina ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Nucl Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[4] Commiss European Communities, Joint Res Ctr, Inst Transuranium Elements, D-7500 Karlsruhe, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NEOFORMANS INFECTION; IONIZING-RADIATION; MENINGITIS; ANTIBODY; MELANIN;

D O I：

10.1086/654813

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with Bi-213-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. Bi-213-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.

引用

页码：633 / 637

页数：5

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