Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis

被引：116

作者：

Chen, Zhao-Fei ^{[1
,2
]}

Ai, Luo-Yan ^{[1
,2
]}

Wang, Ji-Lin ^{[1
,2
]}

Ren, Lin-Lin ^{[1
,2
]}

Yu, Ya-Nan ^{[1
,2
]}

Xu, Jie ^{[1
,2
]}

Chen, Hao-Yan ^{[1
,2
]}

Yu, Jun ^{[3
,4
]}

Li, Min ^{[5
]}

Qin, Wen-Xin ^{[6
]}

Ma, Xiong ^{[1
,2
]}

Shen, Nan ^{[7
]}

Chen, Ying-Xuan ^{[1
,2
]}

Hong, Jie ^{[1
,2
]}

Fang, Jing-Yuan ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Gastroenterol & Hepatol, Shanghai 200001, Peoples R China

[2] Shanghai Inst Digest Dis, Shanghai 200001, Peoples R China

[3] Chinese Univ Hong Kong, Inst Digest Dis, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Clin Lab, Shanghai 200001, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai 200001, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Div Rheumatol, Shanghai 200001, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2015年 / 10卷 / 09期

关键词：

colorectal cancer; gut microbiota; immunity; inflammation; TARGETING SALMONELLA-TYPHIMURIUM; ABERRANT CRYPT FOCI; COLORECTAL-CANCER; LACTOBACILLUS-ACIDOPHILUS; LUNG METASTASIS; MOUSE MODELS; TUMOR; COLON; INHIBITION; MICROBIOTA;

D O I：

10.2217/fmb.15.66

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Aims: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. Materials & methods: The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers. Results & conclusions:C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.

引用

页码：1433 / 1445

页数：13

共 40 条

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Effect of intestinal bacteria on formation of azoxymethane-induced aberrant crypt foci in the rat colon [J].