Functional imaging of developmental and adaptive changes in neurocognition

被引:54
作者
Berl, MM [1 ]
Vaidya, CJ
Gaillard, WD
机构
[1] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Dept Neurosci, Washington, DC 20037 USA
[2] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA
[3] NINDS, Clin Epilepsy Sect, NIH, Bethesda, MD 20892 USA
关键词
development; fMRI; pediatric; cognition; language;
D O I
10.1016/j.neuroimage.2005.10.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Characterization of brain-behavior relationships through functional magnetic imaging (fMRI) within typically or atypically developing populations poses methodological and interpretational challenges. We consider theoretical, methodological, and artifactual factors that influence characterization of developmental and adaptive changes in childhood. Findings from anatomical and physiological brain development studies are highlighted as they may influence functional imaging results. Then, we consider several patterns of functional activation within the context of developmental processes as well as neurologic disease. Hypotheses regarding the development of cognitive networks are proposed to account for the individual differences seen in normal and atypical development. We also identify potential sources of unwanted variability related to experimental design and task performance and suggest possible solutions to help minimize these effects. Lastly, a challenge for current studies is a lack of group and individual analysis methods that can be reliably applied to capture and quantify factors that contribute to variability introduced by developmental and disease processes. We review current methods and propose potential solutions. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:679 / 691
页数:13
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