Ectopic localizations of Golgi glycosyltransferases

被引:32
作者
Berger, EG [1 ]
机构
[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland
关键词
cytoarchitecture; glycosyltransferases; Golgi apparatus; immunocytochemistry; post-Golgi traffic;
D O I
10.1093/glycob/12.2.29R
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycosyltransferases involved in N- and O-glycan chain elongation and termination are localized in the Golgi apparatus. Early evidence in support of this rule was based on fractionation techniques and was corroborated by numerous immunocytochemical studies. Usually these studies were confined to cultured cell lines exhibiting little differentiation features, such as HeLa cells. However, localization studies conducted in primary cell cultures (e.g., human umbilical vein endothelial cells), cells obtained ex vivo (e.g., sperm cells), and tissue sections (e.g., intestinal, renal, or hepatic tissue) often reveal ectopic localizations of glycosyltransferases usually at post-Golgi sites, including the plasma membrane. Hence, extracellular cues resulting from specific adhesion sites may influence post-Golgi trafficking routes, which may be reflected by ectopic localization of Golgi enzymes.
引用
收藏
页码:29R / 36R
页数:8
相关论文
共 84 条
[31]   Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis - Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi [J].
Lannert, H ;
Gorgas, K ;
Meissner, I ;
Wieland, FT ;
Jeckel, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (05) :2939-2946
[32]   GTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COPI vesicles [J].
Lanoix, J ;
Ouwendijk, J ;
Lin, CC ;
Stark, A ;
Love, HD ;
Ostermann, J ;
Nilsson, T .
EMBO JOURNAL, 1999, 18 (18) :4935-4948
[33]   A disulfide-bonded dimer of the Golgi beta-galactoside alpha 2,6-sialyltransferase is catalytically inactive yet still retains the ability to bind galactose [J].
Ma, JY ;
Colley, KJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7758-7766
[34]   Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family [J].
Mandel, U ;
Hassan, H ;
Therkildsen, MH ;
Rygaard, J ;
Jakobsen, MH ;
Juhl, BR ;
Dabelsteen, E ;
Clausen, H .
GLYCOBIOLOGY, 1999, 9 (01) :43-52
[35]   EXPRESSION OF THE HISTO-BLOOD-GROUP ABO GENE DEFINED GLYCOSYLTRANSFERASES IN EPITHELIAL TISSUES [J].
MANDEL, U ;
WHITE, T ;
KARKOV, J ;
HAKOMORI, S ;
CLAUSEN, H ;
DABELSTEEN, E .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1990, 19 (06) :251-256
[36]   EXPRESSION OF HISTO-BLOOD-GROUP-A/B-GENE-DEFINED GLYCOSYLTRANSFERASES IN NORMAL AND MALIGNANT EPITHELIA - CORRELATION WITH A/B-CARBOHYDRATE EXPRESSION [J].
MANDEL, U ;
LANGKILDE, NC ;
ORNTOFT, TF ;
THERKILDSEN, MH ;
KARKOV, J ;
REIBEL, J ;
WHITE, T ;
CLAUSEN, H ;
DABELSTEEN, E .
INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (01) :7-12
[37]   CELL-SURFACE EXPRESSION OF 4-BETA-GALACTOSYLTRANSFERASE ACCOMPANIES RAT PAROTID-GLAND ACINAR CELL TRANSITION TO GROWTH [J].
MARCHASE, RB ;
KIDD, VJ ;
RIVERA, AA ;
HUMPHREYSBEHER, MG .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1988, 36 (04) :453-465
[38]   fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis [J].
Marker, PC ;
Stephan, JP ;
Lee, J ;
Bald, L ;
Mather, JP ;
Cunha, GR .
DEVELOPMENTAL BIOLOGY, 2001, 233 (01) :95-108
[39]  
Narimatsu H, 1996, CANCER RES, V56, P330
[40]  
NGUYEN TTM, 1994, J BIOL CHEM, V269, P28000