Poly(ADP-ribose):: novel functions for an old molecule

被引：1586

作者：

Schreiber, Valerie ^{[1
]}

Dantzer, Francoise ^{[1
]}

Ame, Jean-Christophe ^{[1
]}

de Murcia, Gilbert ^{[1
]}

机构：

[1] Ecole Super Biotechnol Strasbourg, CNRS, Dept Integrite Genome, UMR 7175, F-67412 Illkirch Graffenstaden, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 07期

关键词：

D O I：

10.1038/nrm1963

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.

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收藏

页码：517 / 528

页数：12

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