Poly(ADP-ribose):: novel functions for an old molecule

被引：1586

作者：

Schreiber, Valerie ^{[1
]}

Dantzer, Francoise ^{[1
]}

Ame, Jean-Christophe ^{[1
]}

de Murcia, Gilbert ^{[1
]}

机构：

[1] Ecole Super Biotechnol Strasbourg, CNRS, Dept Integrite Genome, UMR 7175, F-67412 Illkirch Graffenstaden, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 07期

关键词：

D O I：

10.1038/nrm1963

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.

引用

页码：517 / 528

页数：12

共 112 条

[81] Sensing DNA damage by PARP-like fingers [J].

Petrucco, S .

NUCLEIC ACIDS RESEARCH, 2003, 31 (23) :6689-6699

[82] Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity [J].

Pillai, JB ;

Isbatan, A ;

Imai, S ;

Gupta, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (52) :43121-43130

[83] DNA-induced dimerization of poly(ADP-ribose) polymerase-1 triggers its activation [J].

Pion, E ;

Ullmann, GM ;

Amé, JC ;

Gérard, D ;

de Murcia, G ;

Bombarda, E .

BIOCHEMISTRY, 2005, 44 (44) :14670-14681

[84] Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins [J].

Pleschke, JM ;

Kleczkowska, HE ;

Strohm, M ;

Althaus, FR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (52) :40974-40980

[85] POLY(ADP-RIBOSYL)ATION OF POLYNUCLEOSOMES CAUSES RELAXATION OF CHROMATIN STRUCTURE [J].

POIRIER, GG ;

DEMURCIA, G ;

JONGSTRABILEN, J ;

NIEDERGANG, C ;

MANDEL, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3423-3427

[86] Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis [J].

Raval-Fernandes, S ;

Kickhoefer, VA ;

Kitchen, C ;

Rome, LH .

CANCER RESEARCH, 2005, 65 (19) :8846-8852

[87]

REALINI CA, 1992, J BIOL CHEM, V267, P18858

[88] Reconstructing eukaryotic NAD metabolism [J].

Rongvaux, A ;

Andris, F ;

Van Gool, F ;

Leo, O .

BIOESSAYS, 2003, 25 (07) :683-690

[89] Structure of the catalytic fragment of poly(ADP-ribose) polymerase from chicken [J].

Ruf, A ;

DeMurcia, JM ;

DeMurcia, GM ;

Schulz, GE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7481-7485

[90] The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis [J].

Ruf, A ;

Rolli, V ;

de Murcia, G ;

Schulz, GE .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 278 (01) :57-65

← 3 4 5 6 7 8 9 10 11 12 →