Neuroendocrine aspects of polycystic ovary syndrome

被引：83

作者：

Marshall, JC

Eagleson, CA

机构：

[1] Univ Virginia, Sch Med, Ctr Res Reprod, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Med, Div Endocrinol, Charlottesville, VA 22908 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0889-8529(05)70071-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article reviews neuroendocrine aspects of PCOS and compares those aspects to regulation of gonadotropin secretion during normal ovulatory cycles. Reviewed and described are the abnormal patterns of LH secretion in adults and adolescents and mechanisms underlying the persistent rapid frequency of: GnRH secretion. Recent data are presented on the relative insensitivity of the hypothalmic pulse generator to suppression by ovarian steroids. A hypothesis is formulated to explain the evolution of abnormal GnRH secretion during pubertal maturation to the persistent hypersecretion of GnRH and LH in hyperandrogenemic anovulatory adults with PCOS.

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页码：295 / +

页数：31

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