Trophic effects of selegiline on cultured dopaminergic neurons

被引：32

作者：

Kontkanen, O

Castrén, E

机构：

[1] Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland

[2] Univ Kuopio, Dept Psychiat, FIN-70211 Kuopio, Finland

来源：

BRAIN RESEARCH | 1999年 / 829卷 / 1-2期

基金：

芬兰科学院;

关键词：

L-deprenyl; neurite outgrowth; neurotrophic; brain derived neurotrophic factor; Parkinson's disease;

D O I：

10.1016/S0006-8993(99)01363-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trophic effects of the neuroprotective agent selegiline on cultured dopaminergic neurons were investigated and compared with the effects produced by brain derived neurotrophic factor (BDNF). Both treatments increased the total length of TH-positive neurites, but selegiline increased the average length of neuritic branches, whereas BDNF increased the formation of new branches. This trophic effect of selegiline may contribute to its action in neurodegenerative disease treatment. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：190 / 192

页数：3

共 14 条

[1] THE NATURE OF THE TROPHIC ACTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR, DES(1-3)-INSULIN-LIKE GROWTH FACTOR-I, AND BASIC FIBROBLAST GROWTH-FACTOR ON MESENCEPHALIC DOPAMINERGIC-NEURONS DEVELOPING IN CULTURE [J].