Diastereoselective synthesis of syn-3,5-dihydroxyesters via ruthenium-catalyzed asymmetric transfer hydrogenation

被引：25

作者：

Everaere, K

Franceschini, N

Mortreux, A

Carpentier, JF ^{[1
]}

机构：

[1] Univ Rennes 1, Lab Organomet & Catalyse, F-35042 Rennes, France

[2] ENSCL, Lab Chim Organ Appliquee, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

asymmetric transfer hydrogenation; syn-diols; chiral Ru catalysts;

D O I：

10.1016/S0040-4039(02)00310-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric transfer hydrogenation of chiral 5-hydroxy-3-ketoesters in 2-propanol using chlororuthenium(II)arene/ P-amino alcohol in situ catalyst combinations or a pre-synthesized Ru-{beta-amino alcohol} true catalyst, provides syn-3,5-dihydroxyesters in high yields and up to 80% de. (C) (2)002 Elsevier Science Ltd. All rights reserved.

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页码：2569 / 2571

页数：3

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