A substrate combinatorial array for caspases

被引：11

作者：

Lee, D

Adams, JL

Brandt, M

DeWolf, WE

Keller, PM

Levy, MA

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, King Of Prussia, PA 19406 USA

[2] SmithKline Beecham Pharmaceut, Dept Mol Recognit, King Of Prussia, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00260-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1667 / 1672

页数：6

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