Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

被引：109

作者：

Kobayashi, M

Higuchi, K

Murakami, N

Tajima, H

Aoki, S

机构：

[1] Faculty of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(97)00482-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Callystatin A (1) has been isolated from the marine sponge, Callyspongia truncata, and the plane structure, including parts of the absolute configurations, is elucidated. Callystatin A (1) is a novel polyketide with a terminal alpha,beta-unsaturated delta-lactone and exhibited potent cytotoxicity against KB cells at IC50 0.01 ng/ml. (C) 1997 Elsevier Science Ltd.

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页码：2859 / 2862

页数：4

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