Animal virus discovery: improving animal health, understanding zoonoses, and opportunities for vaccine development

被引:55
作者
Delwart, Eric [1 ,2 ]
机构
[1] Blood Syst Res Inst, San Francisco, CA USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
SIMIAN FOAMY VIRUS; PROVENTRICULAR DILATATION DISEASE; CROSS-SPECIES TRANSMISSION; COMPLETE GENOMIC SEQUENCES; HEPATITIS-E VIRUS; DNA VIRUSES; MOLECULAR EPIDEMIOLOGY; DIVERSE ASTROVIRUSES; METAGENOMIC ANALYSIS; IDENTIFICATION;
D O I
10.1016/j.coviro.2012.02.012
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The characterization of viral genomes has accelerated due to improvement in DNA sequencing technology. Sources of animal samples and molecular methods for the identification of novel viral pathogens and steps to determine their pathogenicity are listed. The difficulties for predicting future cross-species transmissions are highlighted by the wide diversity of known viral zoonoses. Recent surveys of viruses in wild and domesticated animals have characterized numerous viruses including some closely related to those infecting humans. The detection of multiple genetic lineages within viral families infecting a single host species, phylogenetically interspersed with viruses found in other host species, reflects past cross-species transmissions. Numerous opportunities for the generation of novel vaccines will arise from a better understanding of animal viromes.
引用
收藏
页码:344 / 352
页数:9
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