Novel circular DNA viruses in stool samples of wild-living chimpanzees

被引：92

作者：

Blinkova, Olga ^{[1
,2
]}

Victoria, Joseph ^{[1
,2
]}

Li, Yingying ^{[3
,4
]}

Keele, Brandon F. ^{[3
,4
]}

Sanz, Crickette ^{[5
]}

Ndjango, Jean-Bosco N. ^{[6
]}

Peeters, Martine ^{[7
,8
]}

Travis, Dominic ^{[9
]}

Lonsdorf, Elizabeth V. ^{[10
]}

Wilson, Michael L. ^{[11
,12
]}

Pusey, Anne E. ^{[12
]}

Hahn, Beatrice H. ^{[3
,4
]}

Delwart, Eric L. ^{[1
,2
]}

机构：

[1] Blood Syst Res Inst, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

[5] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany

[6] Univ Kisangani, Fac Sci, Dept Ecol & Management Plant & Anim Ressources, Kisangani, DEM REP CONGO

[7] Univ Montpellier I, Montpellier, France

[8] Inst Rech Dev, UMR145, Montpellier, France

[9] Lincoln Pk Zoo, Dept Conservat & Sci, Chicago, IL 60614 USA

[10] Lincoln Pk Zoo, Lester E Fisher Ctr Study & Conservat Apes, Chicago, IL 60614 USA

[11] Univ Minnesota, Dept Anthropol, Minneapolis, MN 55455 USA

[12] Univ Minnesota, Jane Goodall Inst, Dept Ecol Evolut & Behav, Ctr Primate Studies, St Paul, MN 55108 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2010年 / 91卷

基金：

美国国家卫生研究院;

关键词：

SINGLE-STRANDED-DNA; FEATHER-DISEASE-VIRUS; NUCLEOTIDE-SEQUENCE ANALYSIS; NECROTIC YELLOWS VIRUS; WASTING SYNDROME PMWS; SOUTH ASIAN CHILDREN; PORCINE-CIRCOVIRUS; VIRAL METAGENOMICS; ENDONUCLEASE DOMAIN; PLANT CIRCOVIRUSES;

D O I：

10.1099/vir.0.015446-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Viral particles in stool samples from wild-living chimpanzees were analysed using random PCR amplification and sequencing. Sequences encoding proteins distantly related to the replicase protein of single-stranded circular DNA viruses were identified. Inverse PCR was used to amplify and sequence multiple small circular DNA viral genomes. The viral genomes were related in size and genome organization to vertebrate circoviruses and plant geminiviruses but with a different location for the stem-loop structure involved in rolling circle DNA replication. The replicase genes of these viruses were most closely related to those of the much smaller (similar to 1 kb) plant nanovirus circular DNA chromosomes. Because the viruses have characteristics of both animal and plant viruses, we named them chimpanzee stool-associated circular viruses (ChiSCV). Further metagenomic studies of animal samples will greatly increase our knowledge of viral diversity and evolution.

引用

页码：74 / 86

页数：13

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