Oleuropein Induces Anti-metastatic Effects in Breast Cancer

被引：64

作者：

Hassan, Zeinab K. ^{[1
,2
]}

Elamin, Maha H. ^{[1
]}

Daghestani, Maha H. ^{[1
]}

Omer, Sawsan A. ^{[1
]}

Al-Olayan, Ebtesam M. ^{[1
]}

Elobeid, Mai A. ^{[1
]}

Virk, Promy ^{[1
]}

Mohammed, Osama B. ^{[1
,3
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Zool, Univ Ctr Women Students, Riyadh 11451, Saudi Arabia

[2] Cairo Univ, Dept Canc Biol, Natl Canc Inst, Cairo, Egypt

[3] Cairo Univ, KSU Mammals Res Chair, Cairo, Egypt

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 09期

关键词：

Breast cancer; oleuropein; metastasis; TIMPs expression; MMPs expression; TISSUE INHIBITOR; MATRIX-METALLOPROTEINASES; OLIVE OIL; BIOLOGICAL-ACTIVITIES; BITTER PRINCIPLE; PROGNOSTIC VALUE; MELANOMA-CELLS; MESSENGER-RNAS; IN-VITRO; EXPRESSION;

D O I：

10.7314/APJCP.2012.13.9.4555

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated that OL may induce anti-metastatic effects on human breast cancer cells. We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially. Treatment of breast cancer cells with oleuropein could help in prevention of cancer metastasis by increasing the TIMPs and suppressing the MMPs gene expressions.

引用

页码：4555 / 4559

页数：5

共 47 条

[1]

Olive Oil Polyphenol Oleuropein Inhibits Smooth Muscle Cell Proliferation [J].