Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds

被引：71

作者：

Chang, Cicero L. T. ^{[1
]}

Lin, Yenshou ^{[2
]}

Bartolome, Arlene P. ^{[3
,4
]}

Chen, Yi-Ching ^{[4
]}

Chiu, Shao-Chih ^{[5
,6
]}

Yang, Wen-Chin ^{[4
,7
,8
,9
]}

机构：

[1] Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan

[2] Natl Taiwan Normal Univ, Dept Life Sci, Taipei 116, Taiwan

[3] Univ Philippines, Inst Chem, Quezon City 1100, Philippines

[4] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[5] China Med Univ, Grad Inst Immunol, Taichung 404, Taiwan

[6] China Med Univ Hosp, Ctr Neuropsychiat, Taichung 404, Taiwan

[7] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

[8] Natl Taiwan Univ, Inst Zool, Taipei 106, Taiwan

[9] Natl Chung Hsing Univ, Dept Life Sci, Taichung 402, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

GLUCAGON-LIKE PEPTIDE-1; INDUCED INSULIN-RESISTANCE; INDUCED OXIDATIVE STRESS; GINSENG BERRY EXTRACT; PANCREATIC BETA-CELL; GINGER ZINGIBER-OFFICINALE; ISLET AMYLOID POLYPEPTIDE; ACTIVATED PROTEIN-KINASE; MATE ILEX-PARAGUARIENSIS; CARTHAMUS-TINCTORIUS L;

D O I：

10.1155/2013/378657

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Diabetes mellitus has been recognized since antiquity. It currently affects as many as 285 million people worldwide and results in heavy personal and national economic burdens. Considerable progress has been made in orthodox antidiabetic drugs. However, new remedies are still in great demand because of the limited efficacy and undesirable side effects of current orthodox drugs. Nature is an extraordinary source of antidiabetic medicines. To date, more than 1200 flowering plants have been claimed to have antidiabetic properties. Among them, one-third have been scientifically studied and documented in around 460 publications. In this review, we select and discuss blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, beta-cell function, GLP-1 homeostasis, and glucose (re)absorption. Emphasis is placed on phytochemistry, anti-diabetic bioactivities, and likely mechanism(s). Recent progress in the understanding of the biological actions, mechanisms, and therapeutic potential of compounds and extracts of plant origin in type 2 diabetes is summarized. This review provides a source of up-to-date information for further basic and clinical research into herbal therapy for type 2 diabetes. Emerging views on therapeutic strategies for type 2 diabetes are also discussed.

引用

页数：33

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