Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid

被引：49

作者：

Assefa, H

Nimrod, A

Walker, L

Sindelar, R ^{[1
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00314-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of semisynthetic analogs of oleanolic acid have been synthesized and tested for their complement inhibitory, cytotoxic and apoptotic activities. Among these, compounds 10 and 17 exhibited complement inhibitory potency superior to oleanolic acid. Both have also shown a moderate improvement in in vitro therapeutic index (T.I.). (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1889 / 1894

页数：6

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