The role of histone deacetylases (HDACs) in human cancer

被引：829

作者：

Ropero, Santiago ^{[1
]}

Esteller, Manel ^{[1
]}

机构：

[1] CNIO, Spanish Natl Canc Ctr, Mol Pathol Programme, Canc Epigenet Lab, Madrid 28029, Spain

来源：

MOLECULAR ONCOLOGY | 2007年 / 1卷 / 01期

关键词：

Histone deacetylases; Cancer; Review;

D O I：

10.1016/j.molonc.2007.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical role in the regulation of gene expression, Histone acetylation induced by histone acetyl transferases (HATs) is associated with gene transcription, while histone hypoacetylation induced by histone deacetylase (HDAC) activity is associated with gene silencing. Altered expression and mutations of genes that encode HDACs have been linked to tumor development since they both induce the aberrant transcription of key genes regulating important cellular functions such as cell proliferation, cell-cycle regulation and apoptosis. Thus, HDACs are among the most promising therapeutic targets for cancer treatment, and they have inspired researchers to study and develop HDAC inhibitors. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：19 / 25

页数：7

共 62 条

[1] RETRACTED: DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2 (Retracted Article) [J].

Bai, SM ;

Ghoshal, K ;

Datta, J ;

Majumder, S ;

Yoon, SO ;

Jacob, ST .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (02) :751-766

[2] SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 [J].

Bouras, T ;

Fu, MF ;

Sauve, AA ;

Wang, F ;

Quong, AA ;

Perkins, ND ;

Hay, RT ;

Gu, W ;

Pestell, RG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (11) :10264-10276

[3] Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors [J].

Bradbury, C ;

Khanim, F ;

Hayden, R ;

Bunce, CM ;

White, DA ;

Drayson, MT ;

Craddock, C ;

Turner, BM .

LEUKEMIA, 2005, 19 (10) :1751-1759

[4] Retinoblastoma protein recruits histone deacetylase to repress transcription [J].

Brehm, A ;

Miska, EA ;

McCance, DJ ;

Reid, JL ;

Bannister, AJ ;

Kouzarides, T .

NATURE, 1998, 391 (6667) :597-601

[5] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[6] Expression profile of histone deacetylase 1 in gastric cancer tissues [J].

Choi, JH ;

Kwon, HJ ;

Yoon, BI ;

Kim, JH ;

Han, SU ;

Joo, HJ ;

Kim, DY .

JAPANESE JOURNAL OF CANCER RESEARCH, 2001, 92 (12) :1300-1304

[7] The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene [J].

Christofori, G ;

Semb, H .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) :73-76

[8] Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase [J].

Cohen, HY ;

Miller, C ;

Bitterman, KJ ;

Wall, NR ;

Hekking, B ;

Kessler, B ;

Howitz, KT ;

Gorospe, M ;

de Cabo, R ;

Sinclair, DA .

SCIENCE, 2004, 305 (5682) :390-392

[9] Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern [J].

Espada, J ;

Ballestar, E ;

Fraga, MF ;

Garea, AV ;

Juarranz, A ;

Stockert, JC ;

Robertson, KD ;

Fuks, FO ;

Esteller, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) :37175-37184

[10] CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future [J].

Esteller, M .

ONCOGENE, 2002, 21 (35) :5427-5440

← 1 2 3 4 5 6 7 →