Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: The HyperGEN study

被引:56
作者
Arnett, DK
Hong, YL
Bella, JN
Oberman, A
Kitzman, DW
Hopkins, PN
Rao, DC
Devereux, RB
机构
[1] Univ Minnesota, Div Epidemiol, Minneapolis, MN 55454 USA
[2] Washington Univ, Div Biostat, St Louis, MO 63110 USA
[3] Case Western Reserve Univ, Cleveland, OH 44106 USA
[4] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA
[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Cardiol Sect, Winston Salem, NC USA
[6] Univ Utah, Dept Cardiovasc Genet, Salt Lake City, UT USA
[7] Cornell Univ, Coll Med, Div Cardiol, New York, NY 10021 USA
关键词
left ventricular hypertrophy; remodeling; echocardiography; race; heritability;
D O I
10.1016/S0895-7061(01)02200-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Evidence suggests that left ventricular (LV) mass is under genetic control, independently of risk factors known to influence LV size and geometry. Methods: As part of the Flypet-GEN study, four field centers recruited African American and white hypertensive siblings (n = 1664). aged 23 to 87 years. Two-dimensionally guided M-mode echocardiography was performed, and LV mass and relative wall thickness (RWT) were measured at a central reading, center. Familial correlations were calculated separately for each ethnic group using maximum likelihood methods, adjusted for the potential confounding, influences of age, gender, systolic blood pressure, and obesity. Results: In African Americans, brother-sister, brother-brother, and sister-sister correlation coefficients and standard errors for LV mass were 0.29 (0.08), 0.44 (0.10). and 0.33 (0.05). In whites, the corresponding correlations were lower than in African Americans at 0.05 (0.08) 0.12 (0.11), and 0.22 (0.09), respectively. Sibling correlation of LV geometry, assessed by RWT, was less in African Americans than in whites: brother-sister, 0.04 (0.10) nu 0.21 (0.10). brother-brother, 0.12 (0.22) nu 0.28 (0.09), and sister-sister, 0.11 (0.07) nu 0.19 (0.11). Conclusions: LV mass is strongly correlated in hypertensive African American siblings, and modestly correlated in their white counterparts whereas RWT has stronger sibling correlation in whites, The patterns of familial correlation of echocardiographic LV mass and RWT suggest that the genetic underpinnings of LV hypertrophy and geometric remodeling may differ among ethnic groups. (C) 2001 American Journal of Hypertension, Ltd.
引用
收藏
页码:1226 / 1230
页数:5
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