Studies in macrolide antibiotic synthesis: The role of tethered alkoxides in titanium alkoxide-mediated regioselective reductive coupling reactions

被引：25

作者：

Bahadoor, AB ^{[1
]}

Micalizio, GC ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1021/ol0600786

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent route to a C1-C15 fragment precursor for erythromycin-based macrolide antibiotics is presented. These studies define a role for tethered alkoxides in the control of site-selective carbon-carbon bond formation in titanium alkoxide-mediated coupling reactions of internal alkynes and chiral aldehydes.

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页码：1181 / 1184

页数：4

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