Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE-/- mice from the development of atherosclerosis

被引：83

作者：

Johnen, Heiko ^{[1
]}

Kuffner, Tamara ^{[1
]}

Brown, David A. ^{[1
]}

Wu, Ben J. ^{[2
]}

Stocker, Roland ^{[2
]}

Breit, Samuel N. ^{[1
]}

机构：

[1] St Vincents Hosp, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2050, Australia

来源：

CARDIOVASCULAR PATHOLOGY | 2012年 / 21卷 / 06期

基金：

英国医学研究理事会;

关键词：

MIC-1; GDF15; ApoE(-/-) mouse model of atherosclerosis; Atherosclerosis pathogenesis; MACROPHAGE INHIBITORY CYTOKINE-1; GROWTH-DIFFERENTIATION FACTOR-15; ACUTE CORONARY SYNDROME; BETA SUPERFAMILY; CANCER; RISK; DIAGNOSIS; MARKER;

D O I：

10.1016/j.carpath.2012.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: MIC-1/GDF15 is a member of the TGF-b superfamily, which is thought to have pleiotropic roles in stress responses, inflammation, tissue injury and repair, energy homeostasis, and malignancy. MIC-1/GDF15 was recently identified as a new biomarker for the development of cardiovascular events and the outcome of atherosclerotic disease therapy. The aim of our study was to determine if MIC-1 also directly exerts pro- or antiatherogenic properties during the development of atherosclerosis. Methods and results: We investigated the effect of transgenic overexpression of MIC-I in macrophages in the ApoE(-/-) mouse model of atherosclerosis. After 6 months of high-fat diet, MIC-1/GDF 15 transgenic ApoE(-/-) mice had smaller atherosclerotic lesions; however, no differences in lesion composition, pro- or anti-inflammatory cytokine production, or serum levels of lipids or cytokines were detected. Conclusions: Our results suggest that MIC-1 has an overall protective effect on the disease process, but further studies will be required to define its mechanism of action. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：499 / 505

页数：7

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