Novel mechanism for the impairment of cell proliferation in HIV-I infection

被引：11

作者：

Bofill, M

Borthwick, NJ

Simmonds, HA

机构：

[1] Royal Free Hosp, Dept Clin Immunol, London NW3 2QG, England

[2] Sch Hyg & Trop Dis, Dept Infect & Trop Dis, London WC1E 7HT, England

[3] Guys Hosp, Purine Res Lab, London SE1 9RT, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(99)01471-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The synthesis of ribonucleotides is essential to cell proliferation. Defects in the relevant metabolic pathways have been demonstrated in stimulated T cells from AIDS patients and are associated with lymphocyte necrotic death. Here, Margarita Bofill and colleagues discuss the possibility that an impaired ribonucleotide metabolism might be common to all. rapidly dividing cells and thus contribute to other recognized symptoms of HIV-1 infection.

引用

页码：258 / 261

页数：4

共 29 条

[1] THE SIGNIFICANCE OF LOW BCL-2 EXPRESSION BY CD45RO-T-CELLS IN NORMAL INDIVIDUALS AND PATIENTS WITH ACUTE VIRAL-INFECTIONS - THE ROLE OF APOPTOSIS IN T-CELL MEMORY [J].