Melatonin as a therapeutic agent in experimental endotoxic shock

被引:80
作者
Maestroni, GJM
机构
[1] Center for Experimental Pathology, Istituto Cantonale di Patologia, Locarno
[2] Center for Experimental Pathology, Istituto Cantonale di Patologia
关键词
LPS; T-helper cells; inflammatory cytokines; septic shock; nitric oxide; therapeutic use;
D O I
10.1111/j.1600-079X.1996.tb00244.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We demonstrated that the pineal neurohormone melatonin exerts immunoregulatory effects via T-helper 2 (Th2) cell products. Th2 products may modulate the secretion and/or action of inflammatory cytokines, which play an important role in the development of septic shock associated with endotoxemia. Here we report that a single melatonin injection protects mice Created with a lethal dose of lipolysaccharide (LPS) especially when melatonin was injected 3 to 6 hr after LPS. This effect did not apparently involve Th cells or inhibition of inflammatory cytokines or macrophage nitric oxide (NO) generation. Nevertheless, plasma nitrate concentration, which reflects the rate of NO synthesis, showed a significant reduction at 18 and 24 hr after LPS administration. Melatonin is being studied in humans for cancer immunotherapy. The data presented here identify melatonin as potential therapy for septic shock.
引用
收藏
页码:84 / 89
页数:6
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