TNF receptor subtype signalling: Differences and cellular consequences

被引：504

作者：

MacEwan, DJ ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Dept Biomed Sci, Aberdeen AB25 2ZD, Scotland

来源：

CELLULAR SIGNALLING | 2002年 / 14卷 / 06期

关键词：

cytokine; receptor; signal transduction; lipase; kinase; phosphatase; protease; calcium homeostasis; G-protein; apoptosis; necrosis; proliferation; inflammation; immune response;

D O I：

10.1016/S0898-6568(01)00262-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation. to inflammatory effects and the mediation of immune responses. to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFRI and TNFR2. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：477 / 492

页数：16

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