Magnetic nanoparticles coated by temperature responsive copolymers for hyperthermia

被引：47

作者：

Aqil, A. ^{[1
]}

Vasseur, S. ^{[2
]}

Duguet, E. ^{[2
]}

Passirani, C. ^{[3
]}

Benoit, J. P. ^{[3
]}

Jerome, R. ^{[1
]}

Jerome, C. ^{[1
]}

机构：

[1] Univ Liege, CERM, B-4000 Liege, Belgium

[2] Univ Bordeaux, CNRS, ICMCB, F-33608 Pessac, France

[3] INSERM, F-49100 Angers, France

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2008年 / 18卷 / 28期

关键词：

D O I：

10.1039/b804003f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Various temperature-responsive N-isopropylacrylamide-based functional copolymers were prepared and used for the stabilization of iron oxide nanoparticles. The copolymers investigated are poly( acrylic acid)-b-poly(N-isopropylacrylamide) (PAA-PNIPAM) and poly(acrylic acid)-b-poly(N-isopropylacrylamide)b-poly(acrylate methoxy poly(ethylene oxide)) (PAA-PNIPAM-PAMPEO), with different molecular weights. The coated nanoparticles were characterized in terms of size by a combination of dynamic light scattering (DLS) and transmission electron microscopy (TEM). A sharp temperature transition was confirmed by particle size measurements vs. temperature. In addition, the stealthiness of the coated nanoparticles has been assessed in vitro by the haemolytic CH50 test. These measurements evidenced the crucial role of the PEO segments on the stealthiness of the nanoparticles and thus that such copolymers are particularly suitable for biomedical applications. Preliminary experiments of alternating magnetic field induced heating were performed and specific absorption rates of the various samples were recorded.

引用

页码：3352 / 3360

页数：9

共 34 条

[11] Magnetite nanoparticle dispersions stabilized with triblock copolymers [J].