The role of NK cells in autoimmune disease

被引:81
作者
Baxter, AG [1 ]
Smyth, MJ [1 ]
机构
[1] Centenary Inst Canc Med & Cell Biol, Newtown, NSW 2042, Australia
基金
英国医学研究理事会;
关键词
NK cells; autoimmune disease; diabetes; systemic lupus erythematosus;
D O I
10.1080/08916930290005864
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
NK cells are a subset of mononuclear cells which have long been suspected of playing an immunoregulatory role in the prevention of autoimmune diseases. Here. we briefly discuss the characteristics of NK cells-particularly what is known of their functional capabilities-and summarise the major findings from studies of NK cells in human and animals susceptible to three major autoimmune diseases: multiple sclerosis, systemic lupus erythematosus and type I (autoimmune) diabetes mellitus, In each case, we present the evidence for an association between disease and deficiencies in NK cells. The prospect of clinical interventions that stimulate NK cell activity are discussed and the current status described.
引用
收藏
页码:1 / 14
页数:14
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