Tranexamic acid reduces blood loss after cementless total hip arthroplasty - prospective randomized study in 40 cases

被引：117

作者：

Yamasaki, S ^{[1
]}

Masuhara, K ^{[1
]}

Fuji, T ^{[1
]}

机构：

[1] Osaka Kosei Nenkin Hosp, Dept Orthopaed Surg, Fukushima Ku, Osaka 5530003, Japan

来源：

INTERNATIONAL ORTHOPAEDICS | 2004年 / 28卷 / 02期

关键词：

D O I：

10.1007/s00264-003-0511-4

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We investigated the effects of tranexamic acid in 40 patients who had received cementless total hip arthroplasty (THA) in a prospective, randomized study. In 20 patients, 1000 mg of whole-body tranexamic acid was administered intravenously 5 min before the operation started. The other 20 patients served as a control group and were operated on without tranexamic acid. Perioperative blood loss was similar in the tranexamic acid group and in the control group. Postoperative blood loss of the tranexamic acid group was significantly less than that of the control group at 2, 4, 6, 8, 10, and 12 h. Regarding time-related changes of postoperative blood loss, significant reduction was observed during the first 2 h after surgery in the tranexamic acid group (P<0.001). After the first 2 h, there was no significant difference between the tranexamic acid group and the control group. Preoperative administration of tranexamic acid decreased postoperative blood loss until 12 h and total bleeding in cementless THA by reduction of blood loss during the first 2 h after surgery.

引用

页码：69 / 73

页数：5

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