Mechanisms shaping fast excitatory postsynaptic currents in the central nervous system

被引:3
作者
Glavinovic, MI [1 ]
机构
[1] McGill Univ, Dept Anaesthesia Res, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Dept Physiol, Montreal, PQ H3G 1Y6, Canada
关键词
D O I
10.1162/089976602753284437
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
How different factors contribute to determine the time course of the basic element of fast glutamate-mediated excitatory postsynaptic currents (mEPSCs) in the central nervous system has been a focus of interest of neurobiologists for some years. In spite of intensive investigations, these mechanisms are not well understood. In this review, basic hypotheses are summarized, and a new hypothesis is proposed, which holds that desensitization of AMPA receptros plays a major role in shaping the time course of fast mEPSCs. According to the new hypothesis, desensitization shortens the time course of mEPSCs largely by reducing the buffering of glutamate molecules by AMPA receptors. The hypothesis accounts for numerous findings on fast mEPSCs and is expected to be equally fruitful as a framework for further experimental and theoretical investigations.
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页码:1 / 19
页数:19
相关论文
共 74 条
[21]  
Glavinovic MI, 1998, PFLUG ARCH EUR J PHY, V435, P193
[22]  
Hausser M, 1997, J PHYSIOL-LONDON, V501, P77
[23]   CHROMOGRANINS - UNIVERSAL PROTEINS IN SECRETORY ORGANELLES FROM PARAMECIUM TO MAN [J].
HELLE, KB .
NEUROCHEMISTRY INTERNATIONAL, 1990, 17 (02) :165-175
[24]   MECHANISMS GENERATING THE TIME COURSE OF DUAL COMPONENT EXCITATORY SYNAPTIC CURRENTS RECORDED IN HIPPOCAMPAL SLICES [J].
HESTRIN, S ;
SAH, P ;
NICOLL, RA .
NEURON, 1990, 5 (03) :247-253
[25]   DIFFERENT GLUTAMATE-RECEPTOR CHANNELS MEDIATE FAST EXCITATORY SYNAPTIC CURRENTS IN INHIBITORY AND EXCITATORY CORTICAL-NEURONS [J].
HESTRIN, S .
NEURON, 1993, 11 (06) :1083-1091
[26]   ACTIVATION AND DESENSITIZATION OF GLUTAMATE-ACTIVATED CHANNELS MEDIATING FAST EXCITATORY SYNAPTIC CURRENTS IN THE VISUAL-CORTEX [J].
HESTRIN, S .
NEURON, 1992, 9 (05) :991-999
[27]   Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation [J].
Holmes, WR .
BIOPHYSICAL JOURNAL, 1995, 69 (05) :1734-1747
[28]   Amplitude and time course of spontaneous and evoked excitatory postsynaptic currents in bushy cells of the anteroventral cochlear nucleus [J].
Isaacson, JS ;
Walmsley, B .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (03) :1566-1571
[29]   ANIRACETAM REDUCES GLUTAMATE RECEPTOR DESENSITIZATION AND SLOWS THE DECAY OF FAST EXCITATORY SYNAPTIC CURRENTS IN THE HIPPOCAMPUS [J].
ISAACSON, JS ;
NICOLL, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10936-10940
[30]   ALLOSTERIC POTENTIATION OF QUISQUALATE RECEPTORS BY A NOOTROPIC DRUG ANIRACETAM [J].
ITO, I ;
TANABE, S ;
KOHDA, A ;
SUGIYAMA, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 424 :533-543