Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

被引：366

作者：

Brown-Elliott, Barbara A. ^{[1
]}

Nash, Kevin A. ^{[2
,3
]}

Wallace, Richard J., Jr. ^{[1
]}

机构：

[1] Univ Texas Hlth Ctr Tyler, Dept Microbiol, Mycobacteria Nocardia Lab, Tyler, TX 75710 USA

[2] Univ So Calif, Childrens Hosp Los Angeles, Dept Pathol & Lab Med, Saban Res Inst, Los Angeles, CA USA

[3] Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA

来源：

CLINICAL MICROBIOLOGY REVIEWS | 2012年 / 25卷 / 03期

关键词：

RAPIDLY GROWING MYCOBACTERIA; INTRINSIC MACROLIDE RESISTANCE; 23S RIBOSOMAL-RNA; BETA-LACTAM RESISTANCE; AVIUM COMPLEX STRAINS; IN-VITRO ACTIVITY; TUBERCULOSIS DIHYDROFOLATE-REDUCTASE; INTERNAL TRANSCRIBED SPACER; PEPTIDYL-TRANSFERASE CENTER; 3RD BIOVARIANT COMPLEX;

D O I：

10.1128/CMR.05030-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Within the past 10 years, treatment and diagnostic guidelines for nontuberculous mycobacteria have been recommended by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA). Moreover, the Clinical and Laboratory Standards Institute (CLSI) has published and recently (in 2011) updated recommendations including suggested antimicrobial and susceptibility breakpoints. The CLSI has also recommended the broth microdilution method as the gold standard for laboratories performing antimicrobial susceptibility testing of nontuberculous mycobacteria. This article reviews the laboratory, diagnostic, and treatment guidelines together with established and probable drug resistance mechanisms of the nontuberculous mycobacteria.

引用

页码：545 / +

页数：39

共 463 条

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