Phosphoinositide 3-kinase controls early and late events in mammalian cell division

被引：117

作者：

García, Z ^{[1
]}

Kumar, A ^{[1
]}

Marqués, M ^{[1
]}

Cortés, I ^{[1
]}

Carrera, AC ^{[1
]}

机构：

[1] CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, E-28049 Madrid, Spain

来源：

EMBO JOURNAL | 2006年 / 25卷 / 04期

关键词：

cancer; cell cycle; p85 regulatory subunit; phosphatidylinositol; 3-kinase;

D O I：

10.1038/sj.emboj.7600967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphoinositide 3- kinase ( PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin- dependent kinases. Fine- tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.

引用

页码：655 / 661

页数：7

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