The phosphoinositide 3-kinase pathway

被引：4593

作者：

Cantley, LC ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02115 USA

来源：

SCIENCE | 2002年 / 296卷 / 5573期

关键词：

D O I：

10.1126/science.296.5573.1655

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidytinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

引用

页码：1655 / 1657

页数：3

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