Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians

被引：32

作者：

Atif, U. ^{[1
]}

Philip, A. ^{[1
]}

Aponte, J. ^{[1
]}

Woldu, E. M. ^{[1
]}

Brady, S. ^{[1
]}

Kraus, V. B. ^{[2
]}

Jordan, J. M. ^{[3
,4
,5
,6
]}

Doherty, M. ^{[7
]}

Wilson, A. G. ^{[8
]}

Moskowitz, R. W. ^{[9
]}

Hochberg, M. ^{[10
]}

Loeser, R. ^{[11
]}

Renner, J. B. ^{[3
,4
,5
,6
]}

Chiano, M. ^{[12
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[5] Univ N Carolina, Dept Orthoped, Chapel Hill, NC USA

[6] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA

[7] Univ Nottingham, Nottingham NG7 2RD, England

[8] Univ Sheffield, Sheffield S10 2TN, S Yorkshire, England

[9] Case Western Reserve Univ, Cleveland, OH 44106 USA

[10] Univ Maryland, Baltimore, MD 21201 USA

[11] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA

[12] GlaxoSmithKline, Harlow, Essex, England

来源：

OSTEOARTHRITIS AND CARTILAGE | 2008年 / 16卷 / 10期

关键词：

Osteoarthritis; Asporin; Genetics; Polymorphism; Hand; Knee;

D O I：

10.1016/j.joca.2008.03.007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (D) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations. The aim of this study was to assess the association of variants in the ASPN gene with the presence of radiographic hand and/or knee CA in a US Caucasian population. Methods: Ten single nucleotide polymorphisms (SNPs) within the ASPN gene were genotyped in 775 affected siblings with radiographically confirmed hand and/or knee OA, and the allelic, genotypic and haplotypic association results were examined. Results: One variant (SNP RS7033979) showed nominal evidence of association with both hand CA (P - 0.042) and knee CA (P - 0.032). Four additional SNPs showed nominal evidence of association with knee CA only. These associations were only observed with genotypic tests; the corresponding allelic and haplotype tests did not corroborate the single-point association results. Conclusion: These data suggest that polymorphisms within ASPN are not a major influence in susceptibility to hand or knee OA in US Caucasians. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：1174 / 1177

页数：4

共 18 条

[1]

Mice deficient in small leucine-rich proteoglycans:: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases [J].