Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis

被引:305
作者
Klein, R
Klein, BEK
Knudtson, MD
Wong, TY
Cotch, MF
Liu, K
Burke, G
Saad, MF
Jacobs, DR
机构
[1] UW Madison, Dept Ophthalmol & Visual Sci, Madison, WI 53726 USA
[2] Univ Melbourne, Ctr Eye Res, Melbourne, Vic, Australia
[3] NEI, NIH, Div Epidemiol & Clin Res, Bethesda, MD 20892 USA
[4] Northwestern Univ, Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
[5] Wake Forest Univ, Dept Publ Hlth Sci, Wake Forest, NC USA
[6] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
[7] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
关键词
D O I
10.1016/j.ophtha.2005.12.013
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To describe the prevalence of age-related macular degeneration (AMD) in 4 racial/ethnic groups (white, black, Hispanic, and Chinese) that participated in the second examination of the Multi-ethnic Study of Atherosclerosis (MESA). Design: Prospective cohort study. Participants: Six thousand one hundred seventy-six 45- to 85-year-old subjects selected from 6 United States communities. Methods: Fundus images were taken using a 450 digital camera through dark-adapted pupils and were graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Main Outcome Measure: Age-related macular degeneration. Results: Prevalences of AMD were 2.4% (black), 4.2% (Hispanic), 4.6% (Chinese), to 5.4% (white) (P < 0.001 for any differences among groups). The highest prevalence of any AMD occurred in those 75 to 84 years old, varying from 7.4% in blacks to 15.8% in whites and Chinese (P = 0.03). Estimated prevalences of late AMD were 0.3% (black), 0.2% (Hispanic), 0.6% (white), and 1.0% (Chinese). These differences were marginally significant (age and gender adjusted, P = 0.08). The frequency of exudative AMD was highest in Chinese (age- and gender-adjusted odds ratio, 4.30; 95% confidence interval, 1.30-14.27) compared with whites. Differences in age, gender, pupil size, body mass index, smoking, alcohol drinking history, diabetes, and hypertension status did not explain the variability among the 4 racial/ethnic groups. Conclusions: Low prevalences of AMD were found in the MESA cohort in all groups. A lower prevalence of AMD was found in blacks compared with whites. The higher prevalence of exudative AMD in Chinese needs further study.
引用
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页码:373 / 380
页数:8
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