The metabolic landscape of cancer stem cells

被引：48

作者：

Dando, Ilaria ^{[1
]}

Dalla Pozza, Elisa ^{[1
]}

Biondani, Giulia ^{[1
]}

Cordani, Marco ^{[1
]}

Palmieri, Marta ^{[1
]}

Donadelli, Massimo ^{[1
]}

机构：

[1] Univ Verona, Biochem Sect, Dept Life & Reprod Sci, I-37134 Verona, Italy

来源：

IUBMB LIFE | 2015年 / 67卷 / 09期

关键词：

cancer stem cells; metabolism; Warburg effect; BREAST-CANCER; PANCREATIC-CANCER; GLUCOSE-METABOLISM; OXIDATIVE-PHOSPHORYLATION; ENERGY-METABOLISM; DRUG-RESISTANCE; SIDE POPULATION; EXPRESSION; INHIBITION; GLYCOLYSIS;

D O I：

10.1002/iub.1426

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cancer stem cells (CSCs) are a sub-population of quiescent cells endowed with self-renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional chemotherapy and radiotherapy imposes a thorough understanding of their biological and biochemical features. The metabolic peculiarities of CSCs may be a therapeutic and diagnostic opportunity in cancer research. In this review, we summarize the most significant discoveries on the metabolism of CSCs describing and critically analyzing the studies supporting either glycolysis or mitochondrial oxidative phosphorylation as a primary source of energy for CSCs. (c) 2015 IUBMB Life, 67(9):687-693, 2015

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收藏

页码：687 / 693

页数：7

相关论文

共 60 条

[1]

F-18 fluorodeoxyglucose-positron emission tomography imaging for primary breast cancer and loco-regional staging [J].

Avril, Norbert ;

Adler, Lee P. .

RADIOLOGIC CLINICS OF NORTH AMERICA, 2007, 45 (04) :645-+

[2]

Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy [J].

Barbato, Daniele Lettieri ;

Vegliante, Rolando ;

Desideri, Enrico ;

Ciriolo, Maria Rosa .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2014, 1845 (02) :317-324

[3]

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy [J].

Bartucci, M. ;

Svensson, S. ;

Romania, P. ;

Dattilo, R. ;

Patrizii, M. ;

Signore, M. ;

Navarra, S. ;

Lotti, F. ;

Biffoni, M. ;

Pilozzi, E. ;

Duranti, E. ;

Martinelli, S. ;

Rinaldo, C. ;

Zeuner, A. ;

Maugeri-Sacca, M. ;

Eramo, A. ;

De Maria, R. .

CELL DEATH AND DIFFERENTIATION, 2012, 19 (05) :768-778

[4]

Unravelling cancer stem cell potential [J].

Beck, Benjamin ;

Blanpain, Cedric .

NATURE REVIEWS CANCER, 2013, 13 (10) :727-738

[5]

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[6]

Understanding and targeting cancer stem cells: therapeutic implications and challenges [J].

Chen, Ke ;

Huang, Ying-hui ;

Chen, Ji-long .

ACTA PHARMACOLOGICA SINICA, 2013, 34 (06) :732-740

[7]

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment [J].

Ciavardelli, D. ;

Rossi, C. ;

Barcaroli, D. ;

Volpe, S. ;

Consalvo, A. ;

Zucchelli, M. ;

De Cola, A. ;

Scavo, E. ;

Carollo, R. ;

D'Agostino, D. ;

Forli, F. ;

D'Aguanno, S. ;

Todaro, M. ;

Stassi, G. ;

Di Ilio, C. ;

De Laurenzi, V. ;

Urbani, A. .

CELL DEATH & DISEASE, 2014, 5 :e1336-e1336

[8]

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets [J].

Cipolleschi, Maria Grazia ;

Marzi, Ilaria ;

Santini, Roberta ;

Fredducci, David ;

Vinci, Maria Cristina ;

D'Amico, Massimo ;

Rovida, Elisabetta ;

Stivarou, Theodora ;

Torre, Eugenio ;

Dello Sbarba, Persio ;

Stecca, Barbara ;

Olivotto, Massimo .

CELL CYCLE, 2014, 13 (02) :268-278

[9]

Cancer stem cells: Models and concepts [J].

Dalerba, Piero ;

Cho, Robert W. ;

Clarke, Michael F. .

ANNUAL REVIEW OF MEDICINE, 2007, 58 :267-284

[10]

Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells [J].

Dando, Ilaria ;

Cordani, Marco ;

Dalla Pozza, Elisa ;

Biondani, Giulia ;

Donadelli, Massimo ;

Palmieri, Marta .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 2015

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