Unravelling cancer stem cell potential

被引：652

作者：

Beck, Benjamin ^{[1
]}

Blanpain, Cedric ^{[2
]}

机构：

[1] Univ Libre Bruxelles ULB, Inst Rech Interdisciplinaire Biol Humaine & Mol I, B-1070 Brussels, Belgium

[2] ULB, IRIBHM, Walloon Excellence Lifesci & Biotechnol WELBIO, B-1070 Brussels, Belgium

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 10期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; LABEL-RETAINING CELLS; IN-VITRO EXPANSION; HEMATOPOIETIC STEM; COLORECTAL-CANCER; SELF-RENEWAL; COLON-CANCER; BETA-CATENIN;

D O I：

10.1038/nrc3597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro clonogenic assays, transplantation and in vivo lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours.

引用

收藏

页码：727 / 738

页数：12

相关论文

共 166 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2] Genetic variegation of clonal architecture and propagating cells in leukaemia [J].

Anderson, Kristina ;

Lutz, Christoph ;

van Delft, Frederik W. ;

Bateman, Caroline M. ;

Guo, Yanping ;

Colman, Susan M. ;

Kempski, Helena ;

Moorman, Anthony V. ;

Titley, Ian ;

Swansbury, John ;

Kearney, Lyndal ;

Enver, Tariq ;

Greaves, Mel .

NATURE, 2011, 469 (7330) :356-+

[3] Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence [J].

Ansieau, Stephane ;

Bastid, Jeremy ;

Doreau, Agnes ;

Morel, Anne-Pierre ;

Bouchet, Benjamin P. ;

Thomas, Clemence ;

Fauvet, Frederique ;

Puisieux, Isabelle ;

Doglioni, Claudio ;

Piccinin, Sara ;

Maestro, Roberta ;

Voeltzel, Thibault ;

Selmi, Abdelkader ;

Valsesia-Wittmann, Sandrine ;

de Fromentel, Claude Caron ;

Puisieux, Alain .

CANCER CELL, 2008, 14 (01) :79-89

[4] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[5] Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres [J].

Bar, Eli E. ;

Lin, Alex ;

Mahairaki, Vasiliki ;

Matsui, William ;

Eberhart, Charles G. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (03) :1491-1502

[6] Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[7] Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[8] Crypt stem cells as the cells-of-origin of intestinal cancer [J].

Barker, Nick ;

Ridgway, Rachel A. ;

van Es, Johan H. ;

van de Wetering, Marc ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

Clarke, Alan R. ;

Sansom, Owen J. ;

Clevers, Hans .

NATURE, 2009, 457 (7229) :608-U119

[9] 3 CLONAL TYPES OF KERATINOCYTE WITH DIFFERENT CAPACITIES FOR MULTIPLICATION [J].

BARRANDON, Y ;

GREEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2302-2306

[10] Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma [J].

Barrett, Lindy E. ;

Granot, Zvi ;

Coker, Courtney ;

Lavarone, Antonio ;

Hambardzumyan, Dolores ;

Holland, Eric C. ;

Hyung-song Nam ;

Benezra, Robert .

CANCER CELL, 2012, 21 (01) :11-24

← 1 2 3 4 5 6 7 8 9 10 →