Unravelling cancer stem cell potential

被引：652

作者：

Beck, Benjamin ^{[1
]}

Blanpain, Cedric ^{[2
]}

机构：

[1] Univ Libre Bruxelles ULB, Inst Rech Interdisciplinaire Biol Humaine & Mol I, B-1070 Brussels, Belgium

[2] ULB, IRIBHM, Walloon Excellence Lifesci & Biotechnol WELBIO, B-1070 Brussels, Belgium

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 10期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; ACUTE MYELOID-LEUKEMIA; LABEL-RETAINING CELLS; IN-VITRO EXPANSION; HEMATOPOIETIC STEM; COLORECTAL-CANCER; SELF-RENEWAL; COLON-CANCER; BETA-CATENIN;

D O I：

10.1038/nrc3597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro clonogenic assays, transplantation and in vivo lineage tracing, have been used to assess the renewing and differentiation potential of normal SCs. Similar strategies have suggested that solid tumours may also be hierarchically organized and contain cancer SCs (CSCs) that sustain tumour growth and relapse after therapy. In this Opinion article, we discuss the different parallels that can be drawn between adult SCs and CSCs in solid tumours.

引用

页码：727 / 738

页数：12

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