Synthesis of Condensed Pyrroloindoles via Pd-Catalyzed Intramolecular C-H Bond Functionalization of Pyrroles

被引：126

作者：

Hwang, Seung Jun

Cho, Seung Hwan

Chang, Sukbok ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 48期

关键词：

D O I：

10.1021/ja806897h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for the synthesis of condensed hetero- or carbocycles such as pyrroloindoles or fluorenes has been developed that involves the Pd-catalyzed cyclization of readily available N-(2-halobenzyl)pyrroles or their phenyl derivatives. The reaction is proposed to proceed via oxidative addition of benzylic halides to Pd(0) followed by base-assisted C-H bond activation. A broad range of condensed cyclic products could be obtained in good to excellent yields under mild conditions.

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页码：16158 / +

页数：3

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