Antitumor antibiotics: Bleomycin, endiynes, and mitomycin

被引：478

作者：

Galm, U

Hager, MH

Van Lanen, SG

Ju, JH

Thorson, JS

Shen, B ^{[1
]}

机构：

[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 02期

关键词：

D O I：

10.1021/cr030117g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.

引用

收藏

页码：739 / 758

页数：20

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