Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

被引：22

作者：

Aouida, M

Tounekti, O

Belhadj, O

Mir, LM

机构：

[1] Inst Gustave Roussy, CNRS, UMR 8121, Lab Vectorol & Transfert Genes, F-94805 Villejuif, France

[2] Fac Sci Tunis, Lab Biochim & Technol, Tunis 1060, Tunisia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 06期

关键词：

D O I：

10.1128/AAC.47.6.2012-2014.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.

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页码：2012 / 2014

页数：3

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