共 43 条
Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells
被引:263
作者:

Montagnani, M
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Golovchenko, I
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Kim, I
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Koh, GY
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Goalstone, ML
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Mundhekar, AN
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Johansen, M
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Kucik, DF
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Quon, MJ
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA

Draznin, B
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA
机构:
[1] NHLBI, Cardiol Branch, NIH, Bethesda, MD 20892 USA
[2] Pohang Univ Sci & Technol, Natl Creat Res Ctr Endothelial Cells, Pohang 790784, South Korea
[3] Univ Alabama Birmingham, Sch Med, Vet Affairs Med Ctr, Res Serv, Birmingham, AL 35294 USA
[4] Univ Alabama Birmingham, Sch Med, Dept Pathol, Birmingham, AL 35294 USA
[5] Univ Calif San Francisco, Program Host Pathogen Interact, San Francisco, CA 94143 USA
[6] Univ Colorado, Sch Med, Vet Affairs Med Ctr, Res Serv, Denver, CO 80220 USA
[7] Univ Colorado, Sch Med, Dept Med, Denver, CO 80220 USA
关键词:
D O I:
10.1074/jbc.M103728200
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The concept of "selective insulin resistance" has emerged as a unifying hypothesis in attempts to reconcile the influence of insulin resistance with that of hyper-insulinemia in the pathogenesis of macrovascular complications of diabetes. To explore this hypothesis in endothelial cells, we designed a set of experiments to mimic the "typical metabolic insulin resistance" by blocking the phosphatidylinositol 3-kinase pathway and exposing the cells to increasing concentrations of insulin ("compensatory hyperinsulinemia"). Inhibition of phosphatidylinositol 3-kinase with wortmannin blocked the ability of insulin to stimulate increased expression of endothelial nitric-oxide synthase, did not affect insulin-induced activation of MAP kinase, and increased the effects of insulin on prenylation of Ras and Rho proteins. At the same time, this experimental paradigm resulted in increased expression of vascular cellular adhesion molecules-1 and E-selectin, as well as increased rolling interactions of monocytes with endothelial cells. We conclude that inhibition of the metabolic branch of insulin signaling leads to an enhanced mitogenic action of insulin in endothelial cells.
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页码:1794 / 1799
页数:6
相关论文
共 43 条
[1]
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
[J].
Abe, H
;
Yamada, N
;
Kamata, K
;
Kuwaki, T
;
Shimada, M
;
Osuga, J
;
Shionoiri, F
;
Yahagi, N
;
Kadowaki, T
;
Tamemoto, H
;
Ishibashi, S
;
Yazaki, Y
;
Makuuchi, M
.
JOURNAL OF CLINICAL INVESTIGATION,
1998, 101 (08)
:1784-1788

Abe, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Yamada, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Kamata, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Kuwaki, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

论文数: 引用数:
h-index:
机构:

Osuga, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Shionoiri, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Yahagi, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Kadowaki, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Tamemoto, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Ishibashi, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Yazaki, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan

Makuuchi, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tokyo, Dept Internal Med 3, Fac Med, Bunkyo Ku, Tokyo 113, Japan
[2]
Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide
[J].
Aljada, A
;
Saadeh, R
;
Assian, E
;
Ghanim, H
;
Dandona, P
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
2000, 85 (07)
:2572-2575

Aljada, A
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA

Saadeh, R
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA

Assian, E
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA

Ghanim, H
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA

Dandona, P
论文数: 0 引用数: 0
h-index: 0
机构:
SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA
[3]
Potentiation of Rho-A-mediated lysophosphatidic acid activity by hyperinsulinemia
[J].
Chappell, J
;
Golovchenko, I
;
Wall, K
;
Stjernholm, R
;
Leitner, JW
;
Goalstone, M
;
Draznin, B
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2000, 275 (41)
:31792-31797

Chappell, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Golovchenko, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Wall, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Stjernholm, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Leitner, JW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Goalstone, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA

Draznin, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Dept Vet Affairs, Res Serv, Denver, CO 80220 USA
[4]
Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers
[J].
Chen, NG
;
Holmes, M
;
Reaven, GM
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
1999, 84 (10)
:3485-3489

Chen, NG
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

Holmes, M
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

Reaven, GM
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
[5]
Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle
[J].
Cusi, K
;
Maezono, K
;
Osman, A
;
Pendergrass, M
;
Patti, ME
;
Pratipanawatr, T
;
DeFronzo, RA
;
Kahn, CR
;
Mandarino, LJ
.
JOURNAL OF CLINICAL INVESTIGATION,
2000, 105 (03)
:311-320

Cusi, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Maezono, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Osman, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Pendergrass, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Patti, ME
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Pratipanawatr, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

DeFronzo, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Kahn, CR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA

Mandarino, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA
[6]
THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR
[J].
DEVRIES, C
;
ESCOBEDO, JA
;
UENO, H
;
HOUCK, K
;
FERRARA, N
;
WILLIAMS, LT
.
SCIENCE,
1992, 255 (5047)
:989-991

DEVRIES, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

ESCOBEDO, JA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

UENO, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

HOUCK, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

FERRARA, N
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

WILLIAMS, LT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143
[7]
Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia
[J].
Draznin, B
;
Miles, P
;
Kruszynska, Y
;
Olefsky, J
;
Friedman, J
;
Golovchenko, I
;
Stjernholm, R
;
Wall, K
;
Reitman, M
;
Accili, D
;
Cooksey, R
;
McClain, D
;
Goalstone, M
.
ENDOCRINOLOGY,
2000, 141 (04)
:1310-1316

Draznin, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Miles, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Kruszynska, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Olefsky, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Friedman, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Golovchenko, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Stjernholm, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Wall, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Reitman, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Accili, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Cooksey, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

McClain, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA

Goalstone, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Colorado, Hlth Sci Ctr, Denver Affairs Med Ctr,Dept Med, Dept Vet Affairs,Res Serv, Denver, CO 80220 USA
[8]
CIRCULATING ADHESION MOLECULES IN DISEASE
[J].
GEARING, AJH
;
NEWMAN, W
.
IMMUNOLOGY TODAY,
1993, 14 (10)
:506-512

GEARING, AJH
论文数: 0 引用数: 0
h-index: 0
机构: Andrew J.H. Gearing is at British Biotechnology PLC, Cowley, Oxfordshire OX4 5LY, Wattington Road

NEWMAN, W
论文数: 0 引用数: 0
h-index: 0
机构: Andrew J.H. Gearing is at British Biotechnology PLC, Cowley, Oxfordshire OX4 5LY, Wattington Road
[9]
Atherosclerosis: The road ahead
[J].
Glass, CK
;
Witztum, JL
.
CELL,
2001, 104 (04)
:503-516

Glass, CK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Specialized Ctr Res Mol Med & Atherosclerosis, Dept Med, La Jolla, CA 92093 USA

Witztum, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Specialized Ctr Res Mol Med & Atherosclerosis, Dept Med, La Jolla, CA 92093 USA
[10]
Insulin stimulates the phosphorylation and activity of farnesyltransferase via the Ras-mitogen-activated protein kinase pathway
[J].
Goalstone, M
;
Carel, K
;
Leitner, JW
;
Draznin, B
.
ENDOCRINOLOGY,
1997, 138 (12)
:5119-5124

Goalstone, M
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS MED CTR,SECT ENDOCRINOL 111H,MED RES SERV,DENVER,CO 80220

Carel, K
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS MED CTR,SECT ENDOCRINOL 111H,MED RES SERV,DENVER,CO 80220

Leitner, JW
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS MED CTR,SECT ENDOCRINOL 111H,MED RES SERV,DENVER,CO 80220

Draznin, B
论文数: 0 引用数: 0
h-index: 0
机构: VET AFFAIRS MED CTR,SECT ENDOCRINOL 111H,MED RES SERV,DENVER,CO 80220