共 91 条
Peptide antigen treatment of naive and virus-immune mice: Antigen-specific tolerance versus immunopathology
被引:109
作者:

Aichele, P
论文数: 0 引用数: 0
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机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

BrduschaRiem, K
论文数: 0 引用数: 0
h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

Oehen, S
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h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

Odermatt, B
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h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

Zinkernagel, RM
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h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

Hengartner, H
论文数: 0 引用数: 0
h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich

Pircher, H
论文数: 0 引用数: 0
h-index: 0
机构: Institute of Experimental Immunology, Department of Pathology, University of Zürich
机构:
[1] Institute of Experimental Immunology, Department of Pathology, University of Zürich
[2] Department of Pathology, University of Zürich
[3] Inst. of Med. Microbiol. and Hygiene, University of Freiburg
来源:
关键词:
D O I:
10.1016/S1074-7613(00)80340-4
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex class I binding peptide, derived from the glycoprotein (GP33 peptide) of lymphocytic choriomeningitis virus (LCMV), specifically tolerized naive cytotoxic T lymphocytes (CTL) when administered three times intraperitoneally in incomplete Freund's adjuvants. However, in the presence of GP33-specific memory CTL in LCMV-primed mice, the same treatment had a general immunosuppressive effect on unrelated third-party antigen-specific T cell responses and caused severe immunopathological damage to the spleen.
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页码:519 / 529
页数:11
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