Peptide antigen treatment of naive and virus-immune mice: Antigen-specific tolerance versus immunopathology

被引:109
作者
Aichele, P
BrduschaRiem, K
Oehen, S
Odermatt, B
Zinkernagel, RM
Hengartner, H
Pircher, H
机构
[1] Institute of Experimental Immunology, Department of Pathology, University of Zürich
[2] Department of Pathology, University of Zürich
[3] Inst. of Med. Microbiol. and Hygiene, University of Freiburg
关键词
D O I
10.1016/S1074-7613(00)80340-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex class I binding peptide, derived from the glycoprotein (GP33 peptide) of lymphocytic choriomeningitis virus (LCMV), specifically tolerized naive cytotoxic T lymphocytes (CTL) when administered three times intraperitoneally in incomplete Freund's adjuvants. However, in the presence of GP33-specific memory CTL in LCMV-primed mice, the same treatment had a general immunosuppressive effect on unrelated third-party antigen-specific T cell responses and caused severe immunopathological damage to the spleen.
引用
收藏
页码:519 / 529
页数:11
相关论文
共 91 条
[1]   VIRUS-LYMPHOCYTE INTERACTION - T-CELLS OF THE HELPER SUBSET ARE INFECTED WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS DURING PERSISTENT INFECTION INVIVO [J].
AHMED, R ;
KING, CC ;
OLDSTONE, MBA .
JOURNAL OF VIROLOGY, 1987, 61 (05) :1571-1576
[2]   PEPTIDE-INDUCED T-CELL TOLERANCE TO PREVENT AUTOIMMUNE DIABETES IN A TRANSGENIC MOUSE MODEL [J].
AICHELE, P ;
KYBURZ, D ;
OHASHI, PS ;
ODERMATT, B ;
ZINKERNAGEL, RM ;
HENGARTNER, H ;
PIRCHER, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :444-448
[3]   Immunopathology or organ-specific autoimmunity as a consequence of virus infection [J].
Aichele, P ;
Bachmann, MF ;
Hengartner, H ;
Zinkernagel, RM .
IMMUNOLOGICAL REVIEWS, 1996, 152 :21-45
[4]   T-CELL PRIMING VERSUS T-CELL TOLERANCE INDUCED BY SYNTHETIC PEPTIDES [J].
AICHELE, P ;
BRDUSCHARIEM, K ;
ZINKERNAGEL, RM ;
HENGARTNER, H ;
PIRCHER, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :261-266
[5]   Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL [J].
AlexanderMiller, MA ;
Leggatt, GR ;
Sarin, A ;
Berzofsky, JA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :485-492
[6]   ANTIGEN-DRIVEN TISSUE-SPECIFIC SUPPRESSION FOLLOWING ORAL TOLERANCE - ORALLY-ADMINISTERED MYELIN BASIC-PROTEIN SUPPRESSES PROTEOLIPID PROTEIN-INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE SJL MOUSE [J].
ALSABBAGH, A ;
MILLER, A ;
SANTOS, LMB ;
WEINER, HL .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (09) :2104-2109
[7]   CD28 INTERACTION WITH B7-COSTIMULATES PRIMARY ALLOGENEIC PROLIFERATIVE RESPONSES AND CYTOTOXICITY MEDIATED BY SMALL, RESTING LYMPHOCYTES-T [J].
AZUMA, M ;
CAYABYAB, M ;
BUCK, D ;
PHILLIPS, JH ;
LANIER, LL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :353-360
[8]   A ROLE FOR CLONAL INACTIVATION IN T-CELL TOLERANCE TO MLS-1A [J].
BLACKMAN, MA ;
BURGERT, HG ;
WOODLAND, DL ;
PALMER, E ;
KAPPLER, JW ;
MARRACK, P .
NATURE, 1990, 345 (6275) :540-542
[9]   T-CELL TOLERANCE BY CLONAL ANERGY IN TRANSGENIC MICE WITH NONLYMPHOID EXPRESSION OF MHC CLASS-II I-E [J].
BURKLY, LC ;
LO, D ;
KANAGAWA, O ;
BRINSTER, RL ;
FLAVELL, RA .
NATURE, 1989, 342 (6249) :564-566
[10]   INVIVO ROLE OF INTERLEUKIN-4 IN T-CELL TOLERANCE INDUCED BY AQUEOUS PROTEIN ANTIGEN [J].
BURSTEIN, HJ ;
ABBAS, AK .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :457-463