Enantioselective synthesis of pentacycloanammoxic acid

被引：83

作者：

Mascitti, V ^{[1
]}

Corey, EJ ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 10期

关键词：

D O I：

10.1021/ja058370g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly effective enantioselective synthesis of pentacycloanammoxic acid (1), an unusual naturally occurring fatty acid from Candidatus Brocadia anammoxidans, has been accomplished. The C20-structure of 1 was assembled with stereocontrol from four building blocks, cyclobutene, 2-cyclopentenone, the chiral silylcyclopentenone 6, and 7-bromoheptanoic acid. Both 1 and its enantiomer are now available in quantities that should facilitate future studies on the mode of biosynthesis which appears to be unprecedented. Copyright © 2006 American Chemical Society.

引用

页码：3118 / 3119

页数：2

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