Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment

被引：38

作者：

Sartorius, A

Vollmayr, B

Neumann-Haefelin, C

Ende, G

Hoehn, M

Henn, FA

机构：

[1] Cent Inst Mental Hlth, D-68159 Mannheim, Germany

[2] Max Planck Inst Neurol Res, Dept Expt Neurol, Cologne, Germany

来源：

NEUROREPORT | 2003年 / 14卷 / 17期

关键词：

creatine; MRS; learned helplessness; ECS; hippocampus; depression;

D O I：

10.1097/00001756-200312020-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabolic changes in the hippocampus formation can be investigated with in vivo magnetic resonance spectroscopy (MRS). Learned helplessness (LH) is a well validated animal model of depression which we established in Sprague-Dawley rats defining some as "learned helpless" (LH) or not "learned helpless" (NLH). Helpless and non-helpless rats received a course of daily administered electroconvulsive shocks (ECS) for 6 days. MRS measurements were performed on a 4.7T animal scanner with an average voxel size within the rat hippocampus of 10 mul. In LH rats hippocampal creatine/NAA rose significantly (14%) whereas creatine/ NAA of NLH rats showed no increase at all. A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed.

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收藏

页码：2199 / 2201

页数：3

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