Role of phospholipase A2 on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases

被引：73

作者：

Boulanger, Y ^{[1
]}

Labelle, M ^{[1
]}

Khiat, A ^{[1
]}

机构：

[1] Univ Montreal, Ctr Hosp, Hop St Luc, Dept Radiol, Montreal, PQ H2X 3J4, Canada

来源：

BRAIN RESEARCH REVIEWS | 2000年 / 33卷 / 2-3期

关键词：

choline; phospholipase A(2); magnetic resonance spectroscopy; brain disease; phospholipids; metabolism;

D O I：

10.1016/S0165-0173(00)00037-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phospholipase Az catalyzes the hydrolysis of membrane glycerophospholipids leading to the production of metabolites observable by both H-1 and P-31 magnetic resonance spectroscopy. The signal of choline-containing compounds (Cho) observed by H-1 magnetic resonance spectroscopy is constituted of metabolites of phosphatidylcholine, especially phosphocholine (PCho) and glycerophosphocholine (GPCho). The phosphomonoester (PME) and phosphodiester (PDE) signals observed by P-31 magnetic resonance spectroscopy are, respectively, precursors and catabolites of phospholipids. A large number of brain diseases have been reported to cause variations in the intensity of the Cho, PME and PDE signals. Changes in the activity of phospholipase A(2) have been measured in many brain diseases. In this review, the relationships between the results of H-1 and P-31 magnetic resonance spectroscopy and the phospholipase A(2) assays are analyzed. In many brain diseases, the variation in the Cho signal intensity can be correlated with a stimulation or inhibition of the phospholipase A(2) activity. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：380 / 389

页数：10

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