Covalent or trapped? PFG diffusion MAS NMR for combinatorial chemistry

被引：9

作者：

Shapiro, MJ

Chin, J

Chen, AD

Wareing, JR

Tang, Q

Tommasi, RA

Marepalli, HR

机构：

[1] Novartis Inst Biomed Res, Dept Analyt, Summit, NJ 07901 USA

[2] Novartis Inst Biomed Res, Dept Metab & Cardiovasc Dis, Summit, NJ 07901 USA

[3] Novartis Inst Biomed Res, Dept Arthrit & Bone Metab, Summit, NJ 07901 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(99)01154-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have demonstrated the ability to distinguish covalently bound compounds from compounds 'trapped' within the resin matrix in high resolution NMR spectra using PFG diffusion NMR. In addition, the signals of the solvent used to swell the resin are also eliminated from the spectrum. PFG diffusion COSY data was used to confirm the structure of the on-resin product. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6141 / 6143

页数：3

共 14 条

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