Allogeneic Platelet-Rich Plasma: At the Dawn of an Off-the-Shelf Therapy?

被引：55

作者：

Anitua, Eduardo ^{[1
,2
]}

Prado, Roberto ^{[2
]}

Orive, Gorka ^{[1
,2
,3
,4
]}

机构：

[1] Eduardo Anitua Fdn Biomed Res, Vitoria, Spain

[2] BTI Biotechnol Inst, Vitoria, Spain

[3] Univ Basque Country EHU, Lab Pharm & Pharmaceut Technol, Fac Pharm, Vitoria, Spain

[4] SLFPB EHU, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Vitoria, Spain

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 02期

关键词：

LARGE BONE DEFECT; KNEE OSTEOARTHRITIS;

D O I：

10.1016/j.tibtech.2016.11.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

A new therapeutic tool is emerging based on a biomimetic strategy: platelet-rich plasma (PRP) technology. Allogeneic off-the-shelf PRP represents a safe and cost-effective treatment for osteoarthritis and related diseases. This breakthrough opens the door not only to improved treatments and opportunities but also to new challenges with multiple uncertainties.

引用

页码：91 / 93

页数：3

共 12 条

[1]

Endogenous morphogens and fibrin bioscaffolds for stem cell therapeutics [J].

Anitua, Eduardo ;

Prado, Roberto ;

Orive, Gorka .

TRENDS IN BIOTECHNOLOGY, 2013, 31 (06) :364-374

[2]

Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study [J].

Bottegoni, Carlo ;

Dei Giudici, Luca ;

Salvemini, Sergio ;

Chiurazzi, Enrico ;

Bencivenga, Rosella ;

Gigante, Antonio .

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2016, 8 (02) :35-41

[3]

Dragoo, Jason L. ;

Korotkova, Tatiana ;

Wasterlain, Amy S. ;

Pouliot, Michael A. ;

Kim, Hyeon Joo ;

Golish, S. Raymond .

OPERATIVE TECHNIQUES IN ORTHOPAEDICS, 2012, 22 (02) :49-55

[4]

IOC consensus paper on the use of platelet-rich plasma in sports medicine [J].

Engebretsen, Lars ;

Steffen, Kathrin ;

Alsousou, Joseph ;

Anitua, Eduardo ;

Bachl, Norbert ;

Devilee, Roger ;

Everts, Peter ;

Hamilton, Bruce ;

Huard, Johnny ;

Jenoure, Peter ;

Kelberine, Francois ;

Kon, Elizaveta ;

Maffulli, Nicola ;

Matheson, Gordon ;

Mei-Dan, Omer ;

Menetrey, Jacques ;

Philippon, Marc ;

Randelli, Pietro ;

Schamasch, Patrick ;

Schwellnus, Martin ;

Vernec, Alan ;

Verrall, Geoffrey .

BRITISH JOURNAL OF SPORTS MEDICINE, 2010, 44 (15) :1072-1081

[5]

Gubina Borut, 2014, Coll Antropol, V38, P865

[6]

Exercise and the platelet activator calcium chloride both influence the growth factor content of platelet-rich plasma (PRP): overlooked biochemical factors that could influence PRP treatment [J].

Hamilton, Bruce ;

Tol, Johannes L. ;

Knez, Wade ;

Chalabi, Hakim .

BRITISH JOURNAL OF SPORTS MEDICINE, 2015, 49 (14) :957-960

[7]

From bench to FDA to bedside: US regulatory trends for new stem cell therapies [J].

Knoepfler, Paul S. .

ADVANCED DRUG DELIVERY REVIEWS, 2015, 82-83 :192-196

[8]

A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma [J].

Sanchez, Mikel ;

Anitua, Eduardo ;

Delgado, Diego ;

Sanchez, Peio ;

Prado, Roberto ;

Jose Goiriena, Juan ;

Prosper, Felipe ;

Orive, Gorka ;

Padilla, Sabino .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2016, 16 (05) :627-643

[9]

Blood to blood [J].

Scudellari, Megan .

NATURE, 2015, 517 (7535) :426-429

[10]

Allogeneic platelet gel with autologous cancellous bone graft for the treatment of a large bone defect [J].

Smrke, Dragica ;

Gubina, Borut ;

Domanovic, Dragoslav ;

Rozman, Primoz .

EUROPEAN SURGICAL RESEARCH, 2007, 39 (03) :170-174

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