The Hallmarks of Ferroptosis

被引：476

作者：

Dixon, Scott J. ^{[1
]}

Stockwell, Brent R. ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[3] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 3 | 2019年 / 3卷

关键词：

glutathione; p53; cell death; chemotherapy; peroxidation; iron; CELL-DEATH; CANCER-CELLS; BUTHIONINE SULFOXIMINE; LIPID-PEROXIDATION; OXIDATIVE STRESS; TUMOR-CELLS; PHASE-I; SELENOPROTEIN SYNTHESIS; STEM-CELLS; IRON;

D O I：

10.1146/annurev-cancerbio-030518-055844

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define ferroptosis, namely: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPX4, the availability of redoxactive iron, and oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids. Several processes including RAS/MAPK signaling, amino acid and iron metabolism, ferritinophagy, epithelial-to-mesenchymal transition, cell adhesion, and mevalonate and phospholipid biosynthesis can modulate susceptibility to ferroptosis. Ferroptosis sensitivity is also governed by p53 and KEAP1/NRF2 activity, linking ferroptosis to the function of key tumor suppressor pathways. Together these findings highlight the role of ferroptosis as an emerging concept in cancer biology and an attractive target for precision cancer medicine discovery.

引用

页码：35 / 54

页数：20

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