Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

被引：360

作者：

Agmon, Eran ^{[1
]}

Solon, Jerome ^{[3
,4
,5
,6
]}

Bassereau, Patricia ^{[3
,4
]}

Stockwell, Brent R. ^{[1
,2
]}

机构：

[1] Columbia Univ, Dept Biol Sci, MC4846,550 West 120th St, New York, NY 10027 USA

[2] Columbia Univ, Dept Chem, MC4846,550 West 120th St, New York, NY 10027 USA

[3] PSL Res Univ, Inst Curie, Lab Phys Chim Curie, CNRS,UMR168, F-75005 Paris, France

[4] Sorbonne Univ, F-75005 Paris, France

[5] Barcelona Inst Sci & Technol, Ctr Genom Regulat, Barcelona, Spain

[6] Univ Pompeu Fabra, Barcelona, Spain

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

OXIDATION; BILAYERS; RAFTS;

D O I：

10.1038/s41598-018-23408-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.

引用

页数：11

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